I have been using the Sergent couplers on my freight trains for some time now, and I do like them a lot. They do a lot for the appearance of the cars. You definitely have to plan a layout where you can reach all the places where trains uncouple though. You use a magnetic want to unlock the couplers. If you follow the assembly and break in steps, which are on the website (sergentengineering.com), they should run without any problems. I have only had problems with the couplers I haven't broken in properly, and those problems have gone away as soon as I took a minute to break them in.
I said I have been using them on freight trains. I have a large fleet of passenger trains, which still use Kadee couplers. There are two reasons for this. For a while you could only get type E couplers from Sergent, and those didn't look right to me on passenger trains. Also, the diaphragms can make it a bit trickier to uncouple the cars, as it is harder to get that magnetic wand in above the couplers. The diaphragms also force the couplers to stay stretched out. Like real couplers, you do need to relieve some of the tension on the couplers before they will open, and this is a little more challenging with the diaphragms.
They do look great though, and operation has never been a problem for me. As soon as Frank starts selling the type H couplers, I will start putting them on my passenger fleet. I'll figure something out for uncoupling them.