My impression is that most I-81 truck traffic in TN and VA is not carrying loads that originate or terminate along I-81, but is traffic from Atlanta, Birmingham, and even the NC Piedmont that needs to get north of Philadelphia, but is avoiding the I-95 mess from Richmond north.
Just came back from Tennessee. Something I noticed -- there are zero straight roads anywhere....
Invariably, you wind up having to go north or south just to go east-west....