At Croton Harmon and Yonkers, there is easy connection to Metro North trains and you shouldn't be waiting very long for one, even on weekends.
Rockingham Racer wrote:New York City's subway system used to be notoriously bad for ADA. I'll admit I don't know the current state of affairs, but elevators seemed to be in short supply, and escalators were often enough not working. I'd take a taxi, given my age and physical condition.The subway system predates the ADA by a century, and NYC MTA's been retrofitting where possible.
The route I mentioned (GCT, S to Times Square, 1/2/3 to Penn Station) has elevators and is accessible. Inside is confusing as *)!*(#$ though.